An exploratory study evaluating the effects of macular carotenoid supplementation in various retinal diseases

An exploratory study evaluating the effects of macular carotenoid supplementation in various retinal diseases

Blog Article

Roxanne Crosby-Nwaobi, Philip Hykin, Tunde Peto, Sobha Sivaprasad NIHR Clinical Research Facility, NIHR Moorfields Biomedical Research Centre, London, UK Purpose: The aim of this study was to assess the impact of daily oral supplementation with Macushield (10 mg/d meso-zeaxanthin, 10 mg/d lutein, and 2 mg/d zeaxanthin) on eye health in patients with retinal diseases by assessing the macular pigment (MP) profile, the visual function, and the quality of life.Methods: Fifty-one patients with various retinal diseases were supplemented daily and followed up for 6 months.The MP optical PEPPERMINT SOAP density was measured using the customized heterochromatic flicker photometry and dual-wavelength autofluorescence.

Visual function was evaluated by assessing the change in best corrected visual acuity, contrast sensitivity, and glare sensitivity in mesopic and photopic conditions.Vision-related and general quality of life changes were determined using the National Eye Insititute- Visual Function Questionnaire-25 (NEI-VFQ-25) and EuroQoL-5 dimension questionnaires.Results: A statistically significant increase in the MP optical density was observed using the dual-wavelength autofluorescence (P=0.

04) DIL Relays but not with the customized heterochromatic flicker photometry.Statistically significant (P<0.05) improvements in glare sensitivity in low and medium spatial frequencies were observed at 3 months and 6 months.

Ceiling effects confounded other visual function tests and quality of life changes.Conclusion: Supplementation with the three carotenoids enhances certain aspects of visual performance in retinal diseases.Keywords: macular pigment optical density, diabetes, central serous retinopathy, age-related macular degeneration.